{"id":645,"date":"2025-12-22T07:39:00","date_gmt":"2025-12-22T07:39:00","guid":{"rendered":"https:\/\/endothemeetings.com.br\/artigos\/?p=645"},"modified":"2025-12-15T19:49:04","modified_gmt":"2025-12-15T19:49:04","slug":"fatores-moleculares-e-celulares-envolvidos-na-patogenese-da-endometriose","status":"publish","type":"post","link":"https:\/\/endothemeetings.com.br\/artigos\/fatores-moleculares-e-celulares-envolvidos-na-patogenese-da-endometriose\/","title":{"rendered":"Fatores Moleculares e Celulares Envolvidos na Patog\u00eanese da Endometriose"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"block-c0c68032-3df1-4e53-8808-28be3b6df5ef\">Artigo original:<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"block-fd6b3f13-644a-4bbc-9ed7-eeeec57f44cc\">The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications<\/h3>\n\n\n\n<p id=\"block-d3b0cfe7-e01f-434c-9564-8f5904852ffc\"><strong>Autores e refer\u00eancia:<\/strong> Mariadas H, Chen JH, Chen KH.<br><strong>Ano:<\/strong> 2025<br><strong>DOI:<\/strong> 10.3390\/ijms26062458<\/p>\n\n\n\n<p id=\"block-fee5783a-71af-48d7-a4e3-06cc64a3d51b\"><strong>Tema cl\u00ednico principal:<\/strong>\u00a0Fatores moleculares e celulares envolvidos na patog\u00eanese da endometriose<br><br><strong>Comentado por:<\/strong> Dra. Graciela Morgado<br>CRM\/SP 122.379 | RQE 540631 | RQE 540632<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Clique para Ler: <\/strong><\/h5>\n\n\n\n<div class=\"wp-block-file botao-artigo has-link-color wp-elements-ddf1d53db283cc6ef4f832c06cc6a164\" style=\"margin-top:-20px\"><a id=\"wp-block-file--media-5d92f740-d486-48a2-8a36-875fccfad2f8\" href=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/The-Molecular-and-Cellular-Mechanisms-of-Endometriosis-From-Basic-Pathophysiology-to-Clinical-Implications.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">The Molecular and Cellular Mechanisms of Endometriosis From Basic Pathophysiology to Clinical Implications<\/a><a href=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/The-Molecular-and-Cellular-Mechanisms-of-Endometriosis-From-Basic-Pathophysiology-to-Clinical-Implications.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-5d92f740-d486-48a2-8a36-875fccfad2f8\">Baixar<\/a><\/div>\n\n\n\n<p id=\"block-fee5783a-71af-48d7-a4e3-06cc64a3d51b\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"block-a94cce24-0891-40f5-9c83-10d5af5731bd\">1. Resumo Cient\u00edfico Objetivo<\/h2>\n\n\n\n<p>Revis\u00e3o narrativa que busca compreender os fatores moleculares associados ao surgimento e desenvolvimento da endometriose, incluindo hip\u00f3teses fisiopatol\u00f3gicas e altera\u00e7\u00f5es celulares e gen\u00e9ticas relevantes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fisiopatologia detalhada<\/h2>\n\n\n\n<p>O artigo explora a teoria do refluxo menstrual como principal hip\u00f3tese etiol\u00f3gica, destacando a falha na depura\u00e7\u00e3o de c\u00e9lulas endometriais vi\u00e1veis na cavidade peritoneal, facilitando sua ades\u00e3o e crescimento ect\u00f3pico.<br>S\u00e3o descritas ainda as propriedades dessas c\u00e9lulas: elevada capacidade de ades\u00e3o, invas\u00e3o e resist\u00eancia \u00e0 apoptose.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"618\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1024x618.png\" alt=\"\" class=\"wp-image-647\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1024x618.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-300x181.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-768x464.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image.png 1287w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">3. Mecanismos moleculares envolvidos<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Presen\u00e7a de <strong>muta\u00e7\u00f5es som\u00e1ticas<\/strong> em genes relacionados \u00e0 apoptose, prolifera\u00e7\u00e3o e imunidade.<\/li>\n\n\n\n<li><strong>Resist\u00eancia \u00e0 progesterona<\/strong> e aumento de receptores de estrog\u00eanio em tecidos ect\u00f3picos.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"774\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1-1024x774.png\" alt=\"\" class=\"wp-image-648\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1-1024x774.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1-300x227.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1-768x580.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-1.png 1150w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Altera\u00e7\u00f5es no microambiente inflamat\u00f3rio com libera\u00e7\u00e3o de citocinas, como <strong>IL-1\u03b2<\/strong>, <strong>IL-6<\/strong> e <strong>TNF-\u03b1<\/strong>.<\/li>\n\n\n\n<li>Ativa\u00e7\u00e3o de vias de sinaliza\u00e7\u00e3o intracelular, como <strong>MAPK<\/strong> e <strong>NF-kB<\/strong>.<\/li>\n\n\n\n<li>Altera\u00e7\u00f5es em <strong>microRNAs<\/strong> envolvidos na regula\u00e7\u00e3o g\u00eanica.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"553\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-2-1024x553.png\" alt=\"\" class=\"wp-image-649\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-2-1024x553.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-2-300x162.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-2-768x415.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/12\/image-2.png 1360w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Estresse oxidativo e papel das esp\u00e9cies reativas de oxig\u00eanio na progress\u00e3o da doen\u00e7a.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">4. An\u00e1lise Coment\u00e1rio Cl\u00ednico da Dra. Graciela<\/h2>\n\n\n\n<p>\u201cO artigo oferece uma s\u00edntese clara e fundamentada dos processos moleculares que sustentam a endometriose. A descri\u00e7\u00e3o das vias inflamat\u00f3rias e dos mecanismos de resist\u00eancia hormonal refor\u00e7a o entendimento de por que essa doen\u00e7a pode ser t\u00e3o resistente ao tratamento cl\u00ednico convencional.&#8221;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. Reflex\u00e3o para o leitor<\/h2>\n\n\n\n<p>Como essas evid\u00eancias moleculares podem nos guiar para terapias mais eficazes e personalizadas? Ainda tratamos todas as pacientes com o mesmo modelo hormonal, mesmo frente a evid\u00eancias de perfis moleculares diversos.<br>Voc\u00ea considera a possibilidade de endometriose em adolescentes com dor p\u00e9lvica refrat\u00e1ria? Quais ferramentas voc\u00ea mais utiliza no consult\u00f3rio para investiga\u00e7\u00e3o precoce sem recorrer diretamente \u00e0 laparoscopia?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Aplica\u00e7\u00f5es Pr\u00e1ticas<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Compreens\u00e3o aprofundada da fisiopatologia da doen\u00e7a para suporte \u00e0 decis\u00e3o cl\u00ednica<\/li>\n\n\n\n<li>Base te\u00f3rica para futuras terapias direcionadas a alvos moleculares<\/li>\n\n\n\n<li>Entendimento das limita\u00e7\u00f5es dos tratamentos hormonais tradicionais<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">7. Refer\u00eancia Completa<\/h2>\n\n\n\n<p>Mariadas H, Chen JH, Chen KH. The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications. Int J Mol Sci. 2025 Mar 10;26(6):2458. doi: 10.3390\/ijms26062458. PMID: 40141102; PMCID: PMC11941934.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" style=\"margin-top:20px;margin-bottom:20px\"\/>\n\n\n\n<p class=\"has-small-font-size\">Neri, L.C.L.; Quintiero, F.; Fiorini, S.; Guglielmetti, M.; Ferraro, O.E.; Tagliabue, A.; Gardella, B.; Ferraris, C. Diet and Endometriosis: An Umbrella Review. Foods 2025, 14, 2087. https:\/\/doi.org\/10.3390\/foods14122087<\/p>\n\n\n\n<p class=\"has-small-font-size\">Este material faz parte do movimento ENDOctors \u2013 The Meetings, e a troca entre colegas \u00e9 parte essencial da nossa evolu\u00e7\u00e3o como m\u00e9dicos. Se quiser compartilhar sua experi\u00eancia, uma d\u00favida ou ponto de vista sobre este tema, envie sua mensagem no grupo \u2014 ser\u00e1 muito bem-vinda!<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Revis\u00e3o narrativa que busca compreender os fatores moleculares associados ao surgimento e desenvolvimento da endometriose, incluindo hip\u00f3teses fisiopatol\u00f3gicas e altera\u00e7\u00f5es celulares e gen\u00e9ticas relevantes.<\/p>\n","protected":false},"author":1,"featured_media":650,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-645","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"_links":{"self":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/comments?post=645"}],"version-history":[{"count":1,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/645\/revisions"}],"predecessor-version":[{"id":651,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/645\/revisions\/651"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/media\/650"}],"wp:attachment":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/media?parent=645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/categories?post=645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/tags?post=645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}