{"id":584,"date":"2025-12-02T08:30:00","date_gmt":"2025-12-02T08:30:00","guid":{"rendered":"https:\/\/endothemeetings.com.br\/artigos\/?p=584"},"modified":"2025-12-12T02:02:03","modified_gmt":"2025-12-12T02:02:03","slug":"fenotipagem-da-endometriose-com-integracao-cirurgica-dados-omicos-e-inteligencia-artificial","status":"publish","type":"post","link":"https:\/\/endothemeetings.com.br\/artigos\/fenotipagem-da-endometriose-com-integracao-cirurgica-dados-omicos-e-inteligencia-artificial\/","title":{"rendered":"Fenotipagem da endometriose com integra\u00e7\u00e3o cir\u00fargica, dados \u00f4micos e intelig\u00eancia artificial"},"content":{"rendered":"\n<p><strong>Autores e refer\u00eancia:<\/strong> Camran R. Nezhat, Tomiko T. Oskotsky, Joshua F. Robinson, Susan J. Fisher, entre outros.<br><strong>Ano:<\/strong> 2025<br><strong>DOI:<\/strong> <a href=\"https:\/\/doi.org\/10.1038\/s44294-024-00052-w\"><\/a><a href=\"https:\/\/doi.org\/10.1038\/s44294-024-00052-w\">10.1038\/s44294-024-00052-w<\/a><\/p>\n\n\n\n<p><strong>T\u00edtulo do artigo:<\/strong><br>Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence <\/p>\n\n\n\n<p id=\"block-fee5783a-71af-48d7-a4e3-06cc64a3d51b\"><strong>Tema cl\u00ednico principal:<\/strong>&nbsp;Fenotipagem de endometriose com enfoque multidisciplinar, incluindo cirurgia, dados \u00f4micos, intelig\u00eancia artificial e integra\u00e7\u00e3o cl\u00ednica.<br><br><strong>Comentado por:<\/strong> Dra. Graciela Morgado<br>CRM\/SP 122.379 | RQE 540631 | RQE 540632<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Clique para Ler: <\/strong><\/h5>\n\n\n\n<div class=\"wp-block-file botao-artigo has-link-color wp-elements-e75ef77f15476fa0da84a1c68cd9321a\" style=\"margin-top:-20px\"><a id=\"wp-block-file--media-63556265-7a44-4f62-b148-dce8f107db28\" href=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/Real-world-perspectives-on-endometriosis-disease-phenotyping-through-surgery-omics-health-data-and-artificial-intelligence-1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence (1)<\/a><a href=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/Real-world-perspectives-on-endometriosis-disease-phenotyping-through-surgery-omics-health-data-and-artificial-intelligence-1.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-63556265-7a44-4f62-b148-dce8f107db28\">Baixar<\/a><\/div>\n\n\n\n<p id=\"block-fee5783a-71af-48d7-a4e3-06cc64a3d51b\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"block-a94cce24-0891-40f5-9c83-10d5af5731bd\">1. Resumo Cient\u00edfico Objetivo<\/h2>\n\n\n\n<p>O artigo apresenta perspectivas contempor\u00e2neas e multidisciplinares sobre a fenotipagem da endometriose, abordando aspectos cir\u00fargicos, moleculares e computacionais. Prop\u00f5e a integra\u00e7\u00e3o de dados cl\u00ednicos, histol\u00f3gicos e \u00f4micos com tecnologias como a IA para aprimorar diagn\u00f3stico, tratamento e estratifica\u00e7\u00e3o da doen\u00e7a.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. Fisiopatologia Detalhada <\/h2>\n\n\n\n<p>A endometriose \u00e9 uma doen\u00e7a sist\u00eamica, estrog\u00eanio-dependente, com forte componente inflamat\u00f3rio e fibrog\u00eanico. Les\u00f5es ect\u00f3picas desencadeiam angiog\u00eanese, inflama\u00e7\u00e3o, fibrose e disfun\u00e7\u00e3o org\u00e2nica. H\u00e1 participa\u00e7\u00e3o de muta\u00e7\u00f5es som\u00e1ticas, dissemina\u00e7\u00e3o retr\u00f3grada, fatores gen\u00e9ticos, imunol\u00f3gicos e ambientais.&#8221;Este estudo escancara um dos maiores gargalos da ginecologia moderna: o atraso diagn\u00f3stico da endometriose. Pacientes passam anos com dor e sintomas debilitantes antes de receberem o nome para sua condi\u00e7\u00e3o. Precisamos de maior conscientiza\u00e7\u00e3o, educa\u00e7\u00e3o m\u00e9dica e protocolos que encurtem essa jornada.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"713\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-7-1024x713.png\" alt=\"\" class=\"wp-image-587\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-7-1024x713.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-7-300x209.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-7-768x535.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-7.png 1198w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">3. Mecanismos Moleculares Envolvidos<\/h2>\n\n\n\n<p>As les\u00f5es compartilham muta\u00e7\u00f5es som\u00e1ticas com o endom\u00e9trio eut\u00f3pico. Dados de transcriptoma e proteoma revelam perfis celulares espec\u00edficos conforme o tipo de les\u00e3o (endometriose superficial, endometriose profunda e endometrioma), com vias envolvidas em inflama\u00e7\u00e3o, fibrose, receptores hormonais e remodelamento de matriz extracelular.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"742\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-8-1024x742.png\" alt=\"\" class=\"wp-image-588\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-8-1024x742.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-8-300x217.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-8-768x557.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-8.png 1174w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"672\" src=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-9-1024x672.png\" alt=\"\" class=\"wp-image-589\" srcset=\"https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-9-1024x672.png 1024w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-9-300x197.png 300w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-9-768x504.png 768w, https:\/\/endothemeetings.com.br\/artigos\/wp-content\/uploads\/2025\/11\/image-9.png 1234w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">4. An\u00e1lise Coment\u00e1rio Cl\u00ednico da Dra. Graciela<\/h2>\n\n\n\n<p>Este artigo \u00e9 um divisor de \u00e1guas na abordagem da endometriose. A proposta de uma fenotipagem integrativa com base em dados cl\u00ednicos reais, dados \u00f4micos e IA pode revolucionar n\u00e3o s\u00f3 o diagn\u00f3stico precoce como tamb\u00e9m personalizar o tratamento conforme o subtipo de les\u00e3o, localiza\u00e7\u00e3o e resposta tecidual.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. Reflex\u00e3o para o leitor<\/h2>\n\n\n\n<p>Quais barreiras ainda enfrentamos na sua pr\u00e1tica para adotar uma abordagem personalizada e integrada na endometriose? Voc\u00ea j\u00e1 pensou em como dados histol\u00f3gicos e moleculares podem guiar sua conduta terap\u00eautica?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Aplica\u00e7\u00f5es Pr\u00e1ticas<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Integra\u00e7\u00e3o de IA na identifica\u00e7\u00e3o de les\u00f5es via imagem<\/li>\n\n\n\n<li>Uso de perfis moleculares para direcionar terapias hormonais<\/li>\n\n\n\n<li>Classifica\u00e7\u00e3o cir\u00fargica detalhada para guiar progn\u00f3stico e reinterven\u00e7\u00f5es<\/li>\n\n\n\n<li>Reconhecimento da heterogeneidade das les\u00f5es para entender falhas terap\u00eauticas<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">7. Refer\u00eancia Completa<\/h2>\n\n\n\n<p>Nezhat CR, Oskotsky TT, Robinson JF, et al. Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence. <em>npj Women&#8217;s Health<\/em>. 2025;3:8. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s44294-024-00052-w\">10.1038\/s44294-024-00052-w<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Este material faz parte do movimento <strong>ENDO \u2013 The Meetings<\/strong>, e a troca entre colegas \u00e9 parte essencial da nossa evolu\u00e7\u00e3o como m\u00e9dicos.<br>Se quiser compartilhar sua experi\u00eancia, uma d\u00favida ou ponto de vista sobre este tema, envie sua mensagem no grupo \u2014 ser\u00e1 muito bem-vinda!<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>O artigo apresenta perspectivas contempor\u00e2neas e multidisciplinares sobre a fenotipagem da endometriose, abordando aspectos cir\u00fargicos, moleculares e computacionais. Prop\u00f5e a integra\u00e7\u00e3o de dados cl\u00ednicos, histol\u00f3gicos e \u00f4micos com tecnologias como a IA para aprimorar diagn\u00f3stico, tratamento e estratifica\u00e7\u00e3o da doen\u00e7a.<\/p>\n","protected":false},"author":1,"featured_media":590,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-584","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"_links":{"self":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/comments?post=584"}],"version-history":[{"count":3,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/584\/revisions"}],"predecessor-version":[{"id":616,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/posts\/584\/revisions\/616"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/media\/590"}],"wp:attachment":[{"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/media?parent=584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/categories?post=584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/endothemeetings.com.br\/artigos\/wp-json\/wp\/v2\/tags?post=584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}